The Pioglitazone microcapsules were formulated with a view to improve the oral bioavailability and to attain the anti hyperglycemic effect within short period of time. The Pioglitazone microcapsules were formulated with Eudragit E100 by using coacervation phase separation technique. Microcapsules were evaluated for various parameters and subjected to the pharmacodynamic studies in healthy albino rabbits. The blood glucose levels were measured and the percent glucose reduction was calculated. The % blood glucose reduction observed from the pure drug and microcapsules was compared. The microcapsules exhibited the desired flow properties and higher dissolution rates. Microcapsules of Pioglitazone showed more anti hyperglycemic activity compared to pure drug.
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